I had the same issue with my Ford Edge 2011 SE, misfire was happening when rpm passed 4k, after several troubleshooting with dealer and spending around $1k they found that it was one of the coils and they replaced with $100 and hopefully the problem solved, I hope this will help your issue.
one thing more, usually misfire happens on cylinder number 1, 2, and 3 because they've been positioned under air inlet and outlet and gets hot a lot, I've replace those numbers fuel injector for more than 2 or 3 times and most of misfire is coming from those ones only.
Regards...