The PCM theory is an even deeper rabbit hole vs the unknown condition of the spark plugs and coils.   2 rounds of plugs and coils of uncertain origin and quality = 2 rounds of uncertainty. Not having a reliable code reader is the reason why your diagnostics is floundering leaving you to guess and assume.   Use the free app Forscan Lite which will work with many but not all OBDII adapters, even many of the cheap OBDII adapters.   Amazon.com: vgate vLinker FD Plus OBD2 Adapter Bluetooth BLE Scanner for FORScan, Work with iPhone, Android, and Windows : Automotive

I would say it's a definite possibility.  Did you ever look up how a PCM operates?   https://www.ryansautomi.com/articles/what-is-the-pcm-on-a-ford-edge.html   https://duckduckgo.com/?ia=web&origin=funnel_home_website_headlinesafari_control&t=h_&q=how+does+the+PCM+in+a+Ford+Edge+work&chip-select=search  

So i guess my real question to this is can the PCM itself cause this high load/low rpm misfire? Assuming i have been using real Motorcraft plugs and coils for the last 150k miles since i've owned this vehicle. 2 rounds of plugs and one round of coils and this problem has been the same for 150k miles.

Good question. I used the BdyCM module and ran it from there. Then double click on the setting to get the enable or disable checkbox. Then wrote out the changes which were successful. The changes were confirmed and stayed that way. But the vehicle went back to the old settings. I am a bit nervous dealing with binary and hex values.  

Ford has had a ton of camera recalls over the past few years, including a bunch of repeat recalls for the same issue due to software issues. If you get a notice, you might as well get the recall work done. It's free and camera problems are annoying. 

Welcome.   What alternator did you purchase and from where did you purchase it?  

Not E85. Plenty of hard core tuned for E85 performance vehicles around me, they are used to getting 150 miles per tank. The smell of of burning is unique and easy to spot. I have never used E85, in an E85 capable vehicle the cost versus mpg doesn't work out. E15 is only 5% more than normal summer gas, and $5 a tank less in the middle of a 3000 mile week is appreciated especially after $5.79 a gallon in CA.

1. Can you do an APIM self test? 2. Are you able to see the part number, calibration level, strategy, calibration, total distance?

I don’t think this is possible. Did the AsBuilt really change? Have you actually compared the hexadecimal values to confirm a change?

Any updates? I have the same exact issue. New battery, new alternator, reset bms, no corrosion on cables, checked connections multiple times. It intermittently stops charging the battery and drops to 12v while driving then kicks back up to 13.5-14v for a few minutes and then back to 12